Erbium in PDB 8u7c: Engineered Nemo Minimal Ikk-Binding Domain

The structure of Engineered Nemo Minimal Ikk-Binding Domain, PDB code: 8u7c was solved by A.E.Kennedy, M.Pellegrini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.23 / 1.44
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	37.514, 40.892, 50.15, 92.62, 106.14, 98.87
R / Rfree (%)	17.3 / 20.2

The structure of Engineered Nemo Minimal Ikk-Binding Domain also contains other interesting chemical elements:

Terbium	(Tb)	3 atoms
Yttrium	(Y)	2 atoms

The binding sites of Erbium atom in the Engineered Nemo Minimal Ikk-Binding Domain (pdb code 8u7c). This binding sites where shown within 5.0 Angstroms radius around Erbium atom.
In total only one binding site of Erbium was determined in the Engineered Nemo Minimal Ikk-Binding Domain, PDB code: 8u7c:

Erbium binding site 1 out of 1 in the Engineered Nemo Minimal Ikk-Binding Domain


Mono view


Stereo pair view

A full contact list of Erbium with other atoms in the Er binding site number 1 of Engineered Nemo Minimal Ikk-Binding Domain within 5.0Å range: probe atom residue distance (Å) B Occ D:Er203 b:13.8 occ:1.00 O4 D:BTB208 2.4 21.0 1.0 O4 D:BTB207 2.4 8.5 1.0 O3 D:BTB207 2.5 11.8 1.0 O D:HOH304 2.5 13.2 1.0 O8 D:BTB207 2.5 15.1 1.0 O6 D:BTB207 2.6 12.4 1.0 N D:BTB207 2.7 9.9 1.0 C2 D:BTB207 3.2 6.6 1.0 C6 D:BTB207 3.3 12.2 1.0 C4 D:BTB207 3.3 8.1 1.0 C3 D:BTB207 3.3 11.0 1.0 C8 D:BTB207 3.4 14.3 1.0 C5 D:BTB207 3.4 12.6 1.0 C4 D:BTB208 3.4 15.0 1.0 C7 D:BTB207 3.5 11.5 1.0 TB D:TB202 3.7 11.2 1.0 O D:HOH302 4.3 29.2 1.0 O8 D:BTB208 4.3 25.8 1.0 OE2 D:GLU60 4.4 22.1 1.0 O3 D:BTB208 4.4 12.5 1.0 OE1 D:GLU60 4.5 15.1 1.0 O D:HOH328 4.6 45.5 1.0 C2 D:BTB208 4.7 15.0 1.0 C1 D:BTB207 4.8 11.0 1.0 OE1 D:GLU56 4.9 10.9 1.0 CD D:GLU60 4.9 15.7 1.0 C8 D:BTB208 4.9 14.2 1.0 C3 D:BTB208 5.0 14.9 1.0 N D:BTB208 5.0 12.9 1.0

A.E.Kennedy, A.H.Barczewski, C.R.Arnoldy, J.P.Pennington, K.A.Tiernan, M.B.Hidalgo, C.C.Reilly, T.Wongsri, M.J.Ragusa, G.Grigoryan, D.F.Mierke, M.Pellegrini. The Structure of A Nemo Construct Engineered For Screening Reveals Novel Determinants of Inhibition Structure 2025.
ISSN: ISSN 0969-2126
DOI: 10.1016/J.STR.2025.01.010